diff --git a/requirements/edx-sandbox/base.txt b/requirements/edx-sandbox/base.txt
index 0f1c4871a9e695767385b2ed2bedd63435ada9d2..6ec232c40fb9ed5a3df7a8f81d170073d74df929 100644
--- a/requirements/edx-sandbox/base.txt
+++ b/requirements/edx-sandbox/base.txt
@@ -4,6 +4,7 @@
 #
 #    make upgrade
 #
+
 common/lib/calc
 common/lib/chem
 common/lib/sandbox-packages
@@ -11,7 +12,7 @@ common/lib/symmath
 asn1crypto==0.24.0
 backports-abc==0.5        # via tornado
 cffi==1.11.5
-cryptography==2.1.4
+cryptography==2.2.2
 enum34==1.1.6
 futures==3.2.0            # via tornado
 idna==2.6
diff --git a/requirements/edx-sandbox/shared.in b/requirements/edx-sandbox/shared.in
index 401c57505df5ecf84207b500bd40b1ca48fd8c3b..f073be0d3f70f67663a13e246e9d6a3ce831729d 100644
--- a/requirements/edx-sandbox/shared.in
+++ b/requirements/edx-sandbox/shared.in
@@ -7,7 +7,7 @@
 #   * confirm that it has no system requirements beyond what we already install
 #   * run "make upgrade" to update the detailed requirements files
 
-cryptography==2.1.4                 # Implementations of assorted cryptography algorithms
+cryptography                        # Implementations of assorted cryptography algorithms
 lxml==3.8.0                         # XML parser
 networkx==1.7                       # Utilities for creating, manipulating, and studying network graphs
 nltk                                # Natural language processing; used by the chem package
diff --git a/requirements/edx-sandbox/shared.txt b/requirements/edx-sandbox/shared.txt
index 14187946835acaffd333475ee969dc1b35e8029b..e9f57b375026e6d7ebca0473c67961da66ac4514 100644
--- a/requirements/edx-sandbox/shared.txt
+++ b/requirements/edx-sandbox/shared.txt
@@ -4,13 +4,14 @@
 #
 #    make upgrade
 #
+
 -e common/lib/calc
 -e common/lib/chem
 -e common/lib/sandbox-packages
 -e common/lib/symmath
 asn1crypto==0.24.0        # via cryptography
 cffi==1.11.5              # via cryptography
-cryptography==2.1.4
+cryptography==2.2.2
 enum34==1.1.6             # via cryptography
 idna==2.6                 # via cryptography
 ipaddress==1.0.22         # via cryptography
diff --git a/requirements/edx/base.txt b/requirements/edx/base.txt
index 4229a8fc89917508dec93d2c59e7ebcf2ca68879..b7f03cde807efc429176963a9b7fea00081b7e9f 100644
--- a/requirements/edx/base.txt
+++ b/requirements/edx/base.txt
@@ -4,6 +4,7 @@
 #
 #    make upgrade
 #
+
 -e git+https://github.com/edx/acid-block.git@e46f9cda8a03e121a00c7e347084d142d22ebfb7#egg=acid-xblock
 -e common/lib/calc
 -e common/lib/capa
@@ -62,7 +63,7 @@ charade==1.0.3            # via pysrt
 click==6.7                # via user-util
 coreapi==2.3.3            # via django-rest-swagger, openapi-codec
 coreschema==0.0.4         # via coreapi
-cryptography==2.1.4
+cryptography==2.2.2
 cssutils==1.0.2           # via pynliner
 ddt==0.8.0
 decorator==4.3.0          # via dogapi, pycontracts
@@ -168,7 +169,7 @@ mock==1.0.1
 mongoengine==0.10.0
 mysql-python==1.2.5
 networkx==1.7
-newrelic==3.2.0.91
+newrelic==3.2.1.93
 nltk==3.3.0
 nodeenv==1.1.1
 numpy==1.6.2
diff --git a/requirements/edx/coverage.txt b/requirements/edx/coverage.txt
index 2ee117248633a7370d6ef9a90a4f4d4446b8a8b8..c721171b4352594d172a109434b7ed4e726160b0 100644
--- a/requirements/edx/coverage.txt
+++ b/requirements/edx/coverage.txt
@@ -4,6 +4,7 @@
 #
 #    make upgrade
 #
+
 coverage==4.2
 diff-cover==0.9.8
 inflect==0.3.1            # via jinja2-pluralize
diff --git a/requirements/edx/development.txt b/requirements/edx/development.txt
index f30190a75cfdfc7b591e2d0be69aee940e524393..3c8dff135998488db4e789fce9046b09fa5a733b 100644
--- a/requirements/edx/development.txt
+++ b/requirements/edx/development.txt
@@ -4,6 +4,7 @@
 #
 #    make upgrade
 #
+
 -e git+https://github.com/edx/acid-block.git@e46f9cda8a03e121a00c7e347084d142d22ebfb7#egg=acid-xblock
 -e common/lib/calc
 -e common/lib/capa
@@ -77,7 +78,7 @@ constantly==15.1.0
 coreapi==2.3.3
 coreschema==0.0.4
 coverage==4.2
-cryptography==2.1.4
+cryptography==2.2.2
 cssselect==1.0.3
 cssutils==1.0.2
 ddt==0.8.0
@@ -215,7 +216,7 @@ moto==0.3.1
 mysql-python==1.2.5
 needle==0.5.0
 networkx==1.7
-newrelic==3.2.0.91
+newrelic==3.2.1.93
 nltk==3.3.0
 nodeenv==1.1.1
 nose==1.3.7
@@ -259,7 +260,7 @@ pylint-plugin-utils==0.2.6
 pylint==1.7.1
 pymongo==2.9.1
 pynliner==0.5.2
-pyopenssl==17.5.0
+pyopenssl==18.0.0
 pyparsing==2.2.0
 pyquery==1.4.0
 pysqlite==2.8.3
@@ -313,7 +314,7 @@ sphinxcontrib-websupport==1.0.1  # via sphinx
 splinter==0.8.0
 sqlparse==0.2.4           # via django-debug-toolbar
 stevedore==1.10.0
-sure==1.4.10
+sure==1.4.11
 sympy==0.7.1
 testfixtures==6.0.2
 testtools==2.3.0
@@ -331,7 +332,7 @@ uritemplate==3.0.0
 urllib3==1.22
 urlobject==2.4.3
 user-util==0.1.3
-virtualenv==15.2.0
+virtualenv==16.0.0
 voluptuous==0.11.1
 w3lib==1.19.0
 watchdog==0.8.3
diff --git a/requirements/edx/paver.txt b/requirements/edx/paver.txt
index f00bbe947b77e3867c9c9e41023e2be90a1b8990..fe881ec7897821d98a3a98754664ac9f7431c065 100644
--- a/requirements/edx/paver.txt
+++ b/requirements/edx/paver.txt
@@ -4,6 +4,7 @@
 #
 #    make upgrade
 #
+
 argh==0.26.2              # via watchdog
 argparse==1.4.0           # via stevedore
 edx-opaque-keys==0.4.4
diff --git a/requirements/edx/pip-tools.txt b/requirements/edx/pip-tools.txt
index e7027f3fb21c5071c9b7628a407345d2b12bd001..44aa65b2a3db3f7d157707ec5a6a178b34be3a38 100644
--- a/requirements/edx/pip-tools.txt
+++ b/requirements/edx/pip-tools.txt
@@ -4,6 +4,7 @@
 #
 #    make upgrade
 #
+
 click==6.7                # via pip-tools
 first==2.0.1              # via pip-tools
 pip-tools==2.0.2
diff --git a/requirements/edx/testing.txt b/requirements/edx/testing.txt
index 829e5e50de9b30969c221779f8223360fdd53f45..e5adb74a905ba80780eb0fc7c848a9ba3c0af3f3 100644
--- a/requirements/edx/testing.txt
+++ b/requirements/edx/testing.txt
@@ -4,6 +4,7 @@
 #
 #    make upgrade
 #
+
 -e git+https://github.com/edx/acid-block.git@e46f9cda8a03e121a00c7e347084d142d22ebfb7#egg=acid-xblock
 -e common/lib/calc
 -e common/lib/capa
@@ -74,7 +75,7 @@ constantly==15.1.0        # via twisted
 coreapi==2.3.3
 coreschema==0.0.4
 coverage==4.2
-cryptography==2.1.4
+cryptography==2.2.2
 cssselect==1.0.3
 cssutils==1.0.2
 ddt==0.8.0
@@ -207,7 +208,7 @@ moto==0.3.1
 mysql-python==1.2.5
 needle==0.5.0             # via bok-choy
 networkx==1.7
-newrelic==3.2.0.91
+newrelic==3.2.1.93
 nltk==3.3.0
 nodeenv==1.1.1
 nose==1.3.7
@@ -248,7 +249,7 @@ pylint-plugin-utils==0.2.6  # via pylint-celery, pylint-django
 pylint==1.7.1             # via edx-lint, pylint-celery, pylint-django, pylint-plugin-utils
 pymongo==2.9.1
 pynliner==0.5.2
-pyopenssl==17.5.0         # via scrapy, service-identity
+pyopenssl==18.0.0         # via scrapy, service-identity
 pyparsing==2.2.0
 pyquery==1.4.0
 pysqlite==2.8.3
@@ -297,7 +298,7 @@ sorl-thumbnail==12.3
 sortedcontainers==0.9.2
 splinter==0.8.0
 stevedore==1.10.0
-sure==1.4.10
+sure==1.4.11
 sympy==0.7.1
 testfixtures==6.0.2
 testtools==2.3.0          # via fixtures, python-subunit
@@ -314,7 +315,7 @@ uritemplate==3.0.0
 urllib3==1.22
 urlobject==2.4.3          # via pa11ycrawler
 user-util==0.1.3
-virtualenv==15.2.0        # via tox
+virtualenv==16.0.0        # via tox
 voluptuous==0.11.1
 w3lib==1.19.0             # via parsel, scrapy
 watchdog==0.8.3